The function of dendritic spines: devices subserving biochemical rather than electrical compartmentalization
نویسندگان
چکیده
منابع مشابه
The function of dendritic spines: devices subserving biochemical rather than electrical compartmentalization.
Dendritic spines are tiny, specialized protoplasmic protuberances that cover the surface of many neurons. First described by Ramon y Cajal ( 1991) in light microscopic studies of Golgistained tissue, they are among the most striking subcellular features of many neurons. Spines serve as the major target for excitatory synaptic input onto principal neurons in the hippocampus, the neocortex, and o...
متن کاملElectrical compartmentalization in dendritic spines.
Most excitatory inputs in the CNS contact dendritic spines, avoiding dendritic shafts, so spines must play a key role for neurons. Recent data suggest that, in addition to enhancing connectivity and isolating synaptic biochemistry, spines can behave as electrical compartments independent from their parent dendrites. It is becoming clear that, although spines experience voltages similar to those...
متن کاملElectrical Advantages of Dendritic Spines
Many neurons receive excitatory glutamatergic input almost exclusively onto dendritic spines. In the absence of spines, the amplitudes and kinetics of excitatory postsynaptic potentials (EPSPs) at the site of synaptic input are highly variable and depend on dendritic location. We hypothesized that dendritic spines standardize the local geometry at the site of synaptic input, thereby reducing lo...
متن کاملStructure and function of dendritic spines.
Spines are neuronal protrusions, each of which receives input typically from one excitatory synapse. They contain neurotransmitter receptors, organelles, and signaling systems essential for synaptic function and plasticity. Numerous brain disorders are associated with abnormal dendritic spines. Spine formation, plasticity, and maintenance depend on synaptic activity and can be modulated by sens...
متن کامل[Structure-stability-function relationships of dendritic spines].
Dendritic spines, which receive most of the excitatory synaptic input in the cerebral cortex, are heterogeneous with regard to their structure, stability and function. Spines with large heads are stable, express large numbers of AMPA-type glutamate receptors, and contribute to strong synaptic connections. By contrast, spines with small heads are motile and unstable and contribute to weak or sil...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Neuroscience
سال: 1993
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.13-02-00413.1993